Do Intermittent Fasting Benefits Include Living Longer?

intermittent fasting benefits“We’ve known for a long time that if you reduce the calorie intake of rats or mice, they live much longer,” says Mark Mattson, chief of the laboratory of neurosciences at the National Institute on Aging (NIA) in Baltimore. Do these intermittent fasting benefits carry over to humans?

What happens in species closer to humans is more complicated. Rhesus monkeys fed 30 percent fewer calories lived longer in a study at the University of Wisconsin, but not in a study at the NIA.


Why the different results?

One possibility: The Wisconsin monkeys were fed fewer calories than monkeys fed as much high-sugar, high-fat food as they wanted. In contrast, the NIA monkeys were fed fewer calories than monkeys fed as much (low-sugar, low-fat) food as they needed to maintain their weight.

“One take-home message is that if you are an overweight monkey like those in Wisconsin, cutting back on calories will extend your lifespan,” says Mattson. “Whereas if you are eating a healthy diet and not overweight like the NIA monkeys, cutting back on calories may not extend your life, although you may experience some health benefits.”

What if you’re human?

In the first good study in normal-weight or slightly overweight (but not obese) people, researchers asked roughly 150 men and women to consume 25 percent fewer calories at each meal than they needed to maintain their weight, and 75 similar people to follow their normal diet, for two years.

The calorie cutters managed to eat 12 percent fewer calories, and they lost 10 percent of their body weight. That may explain why their blood pressure was lower and their insulin worked better than those who ate their normal diets.

“They lowered their risk factors for heart attack, stroke, and diabetes,” says Eric Ravussin, director of the Nutrition Obesity Research Center at the Pennington Biomedical Research Center in Baton Rouge, Louisiana.

Why didn’t the calorie cutters cut more? “Eating less than you would like to every day is a struggle,” says Ravussin. “Some people can do it, but many cannot.”

But cutting calories only on some days (or intermittent fasting) may be easier.

Mon, Tues, Weds, Thurs, Fri, Sat, Sun

“There’s the alternate-day modified fast,” says Ravussin. “Every other day you eat only one meal with maybe 30 percent of your normal daily calorie intake.”

And there’s the 5:2 diet, in which you eat a normal diet five days of the week, and only 30 percent of what you would normally eat on the other two days.

“Whichever it is, you have to make sure you don’t overeat on the normal days,” cautions Ravussin.

Intermittent fasting benefits seem promising in both animals and people

“Laboratory animals that get no food at all on alternate days live about 30 percent longer than animals that eat their regular diets every day,” says Mattson.

In humans, the 5:2 plan seems to hold an edge over fasting every  day.

In two of the best studies, Mattson and colleagues divided 166 overweight middle-aged women into two groups. Both were told to cut calories by 25 percent—one by trimming the calories in each meal, the other by following a 5:2 plan.

In both studies, the women were told to eat a high-protein “Mediterranean-type” diet with fruits, vegetables, whole grains, nuts, seafood, and olive oil, and only moderate amounts of dairy, poultry, eggs, and lean red meat.

On the two fasting days of the 5:2 diet, one study prescribed just four cups of low-fat milk, four servings of vegetables, and one serving of fruit. The other study prescribed about 9 oz. of lean protein, 3 servings of low-fat dairy, 4 servings of low-carb vegetables, and a low-carb fruit. Both also recommended low-calorie drinks and a multivitamin-and-mineral.

In each study, both calorie-cutting groups lost about the same weight. “But insulin resistance declined more in the 5:2 groups than in those who cut calories daily,” says Mattson. And in the three-month trial (the other trial lasted six months) the women on the 5:2 regimen lost more body fat.

Why did the 5:2 dieters do better? They were more likely to stick to their plan. “And on the two days that they ate only 500 to 600 calories, their metabolism shifted to burning fat,” says Mattson.

Does intermittent fasting benefit the brain?

Middle-aged rats went on a brain diet, after being deprived of all food every other day for three months, lost 23 percent of their body weight and had better motor coordination and cognitive skills than similar rats who could eat all they wanted.

One possible reason: “Intermittent fasting benefits include increased brain levels of a protein that stimulates the growth of new brain cells and the connections between them,” says Mattson.

“We think what’s happening is that when you’re hungry, your brain cells are more active so you can figure out how to find food,” he explains. “During evolution, those who were able to figure out how to get food were the ones who survived.”

Today, our brain cells may respond in a similar way when we’re hungry.

Other intermittent fasting benefits include the possibility of postponing dementia, at least in animals. In mice bred to show signs of Alzheimer’s disease by middle age, eating only every other day delays the onset of dementia by the human equivalent of about 10 years.

“That’s a big effect,” says Mattson. “But we’re nowhere near being able to say the same about humans.”

The bottom line: Cutting calories may not prolong your life, but it may lower your blood pressure and make your insulin work better.

Do you have experience with intermittent fasting? What results did you get? Let us know in the comments. 

Sources: Science 325: 201, 2009; Nature 489: 318, 2012; Mech. Ageing Dev. 55: 69, 1990; Int. J. Obes. 35: 714, 2011; Br. J. Nutr. 110: 1534, 2013; Age 34: 917, 2012; Endocrinology 144: 2446, 2003; Neurobiol. Dis. 26: 212, 2007.

This article was originally published in 2014 and is updated regularly. 

10 Replies to “Do Intermittent Fasting Benefits Include Living Longer?”

  1. Sounds interesting, but the food described comes to more like 700 to 800 calories or more per day for the milk and produce and lots more for the high protein. Has anyone tried this at 500-600 calories?

  2. Yes, and it’s easier than one might think. On the low calorie days, don’t eat your breakfast of a couple of boiled eggs and an apple until about 10:00. That will get you to 6:00 when you can eat another meal of fish or chicken with a big salad with low calorie dressing. A side benefit is that is help you build willpower for the days when you are eating “normally.”

  3. Intermittent fasting really does work. I started back in April after working hard to lose 10 pounds the months previously, and by the end of May I had easily lost 8 more. I have a lot of weight to lose, more than fifty, so I shoot for 300 calories 12 hours apart. 7 AM then 7 PM. That way I don’t eat after 7 the night before so it is 12 hrs til breakfast then 12 hrs til dinner then another 12 hrs until the fast breaks. Even with it being summer fruits and barbecues I have lost 25 lbs with little effort. On fasting days I only eat protein and slow carb green vegetables. I’m 50 and peri menopause so anyone who is around my age knows how hard it can be to lose weight and keep it off. The 5:2 is easy and effective. When I plateau I’ll move down to 250 calories and maybe add in another day of fasting every other week.

  4. If following the 5:2 intermittent fasting structure, should the two fasting days be subsequent or can they be separated? Another question – would the days with minimal calorie intake detrimentally affect physical activity? Might one feel weak on these low-calorie days and under-perform on workouts?

  5. I had great success with fasting 16 hours every day from a late lunch. Then I read some research which compared weight loss among fasters, and people on restricted calorie diets. Both lost about the same amount of weight, but only the restricted calorie eaters lost all fat, the fasting group lost mostly mixed tissue. I am assuming that during the fasting period the body cannibalised itself in desperation, whereas as the restricted calorie eaters used up unwanted fat reserves. So I am trying now to restrict calories but keep up a balanced three meal a day diet.

  6. I have done the 5/2 and found it very doable. It sort of helps reset you taste buds, helps you understand that hunger occurs more in your throat area then stomach and helps me with self control overall. However I just water fast on the 2 non-consecutive days instead of eating the 500-600 calories. One other thing I did not see mentioned but a study found is intermittent fasting will reduce the IGF-1 hormone, which is generally a good thing.

  7. My husband and I have done both variations of the fasting diet (he, restricted daily; me, 5:2) for about a year now. We do it in hopes of staving off Alzheimers disease which is in our family histories. We both started out thin and dropped about 7 lbs. He restricts by starting food intake at noon and ending by 8pm every day but eats a normal amount and has no trouble at all. I find it easier to fast ( 480 calories) for 2 consecutive days and then eat normally for 5. I am very hungry by the end of each fasting day, particularly since I continue to exercise on fast days. Surprisingly, when I awake on the day after the fasting days, I’m not hungry at all. My husband and I are in our late sixties.

  8. Thoughts on intermittent fasting just during the night hours? They should do studies that involve fasting during the night hours (example: 7PM to 7AM, or 10PM to 10AM for those late dinner eaters). My clients striving for weight loss generally have good results with such a 12-hr nightly fast. You would be surprised how most people do not allow themselves (or their stomachs for that matter) to rest at night.

  9. I have been on the 16/8 fast, 7 days a week for about 9 months. I did not want to give up breakfast, since it’s my fav meal, so I eat from 7:00 am to 3:00 pm then stop. It’s been incredibly effective and easy for me. ( I also cut out added sugars during the same time) I am amazed – given my love affair with food- that I do not feel hungry. I eat two regular, healthy meals and have lost fat and weight. The fat loss has been particularly amazing. Having said all this, I started this because my mother had both Alzheimer’s and Parkinson’s and I do not want to go down that painful road if I can avoid it. Animal research looks promising and I am hoping it translates to humans. Guinea pig 101!!

  10. I am very glad to read this article since I have been doing a one day fast each week for months and found it feels good, doesn’t slow me down, in fact the opposite and I have lost aprox a lb per month which doesn’t sound like much but it is going the right way for a change and it is doable so long term! I will now step it up to 2 days each week in which I stick to liguids with nutrition and low fat and sugar, it does make food taste better on the non fasting days too! I’m glad to read of the health benefits!

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