Good News for People Taking Glucosamine and Chondroitin for their Joints

Millions of people take the dietary supplements glucosamine and chondroitin to relieve the pain of osteoarthritis in their knees, hips, and fingers. Some also buy the supplements for their arthritic pets.

But because supplements are only loosely regulated by the Food and Drug Administration, you can’t be sure about the quality of these products.  Does your supplement have what it’s supposed and in the right amounts?

To find out about joint supplements, recently tested 26 popular glucosamine and chondroitin products for people and 6 for pets. ( is a private company that’s been testing the quality of supplements since 1999.)

Good news

The good news is that all 26 products that contained glucosamine or chondroitin or both really did contain these compounds and in the amounts listed on the label. So it looks like your odds are good for picking out a quality brand.

Not so good newsJoint Pain

However, your pet may not be so fortunate. Two of the six pet supplements that tested did not contain enough glucosamine or chondroitin and a third had too much arsenic!

We can’t tell you which brands were good and which were not. supports itself by selling subscriptions to its results. It couldn’t stay in business if people gave away their information for free. And we do want them to continue their work because they’re the only outfit that regularly tests supplements. The government doesn’t do it.

So, is glucosamine and chondroitin worth taking for osteoarthritis?

The answer isn’t clear.

Glucosamine is a compound made by our bodies that helps form cartilage. At least 25 randomized controlled trials over the last three decades haven’t produced a consensus about whether glucosamine pills are more effective than a placebo.

“Glucosamine doesn’t work, period,” says arthritis expert David Felson of the Boston University School of Medicine.

Not so certain is Roland Moskowitz of the University Hospitals Case Medical Center in Cleveland. “There are reasons to think that it may help, and some studies that suggest it does,” he counters. Yet Moskowitz helped run the National Institutes of Health’s GAIT trial, which found that glucosamine doesn’t work.

Two forms of glucosamine

One reason for the uncertainty: there are two forms of glucosamine. Glucosamine hydrochloride–the kind in most supplements and the one used in the GAIT trial—was no better than a placebo in three studies.

Glucosamine sulfate, on the other hand, seems to relieve pain and improve function, according to the Cochrane Collaboration, a network of scientists who review the evidence for medical therapies.

But all nine trials that found a benefit were funded and run by the supplement industry, usually by the Italian manufacturer of one glucosamine sulfate formulation. In the three trials that were conducted by independent investigators, glucosamine sulfate was no better than a placebo.

Despite the lack of evidence, Felson doesn’t talk his patients out of trying glucosamine. “If they think something is working and it’s not dangerous, I don’t discourage its use.”


Our bodies also make chondroitin, which provides some of cartilage’s resistance to pressure. In the more rigorous trials, chondroitin alone didn’t relieve arthritis pain better than a placebo.

A combination of the two?

In the GAIT trial, taking glucosamine hydrochloride plus chondroitin every day for six months didn’t relieve pain or improve joint function any more than a placebo for 317 people with osteoarthritis of the knee. At first, researchers thought that the combination may have helped just the 57 participants who started the trial with moderate-to-severe pain. But when they monitored participants for two more years, they saw no benefit.


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6 Replies to “Good News for People Taking Glucosamine and Chondroitin for their Joints”

  1. I don’t know about all the scientific data. What I DO know, is that when I stop taking glucosamine/condrontin/ MSM, I am very stiff and in extreme pain. I work out regularly, and I cannot afford this. I am 69 years. I have taken this supplement for 15-20 years. It works for me and enables me to live a productive life.

      1. Hi,
        I’m not Alice but I can relate my experience. About twelve years ago my doctor told me that some people were getting relief from arthritis such as I was complaining about from glucosamine.supplements. I tried several brands with at best an “iffy” response. Then a pharmacist friend suggested a particular brand which was different from all the ones I had tried in being vegetarian, that is it was made by synthesis instead of being derived from shellfish (and therefore being suitable for those with an allergy to the latter). Well I tried it and the results were amazing. I could tell something was happening within a couple of weeks and after a couple of months it had not only arrested the deterioration but had rolled back at least five years worth of previous deterioration. Unfortunately, after about ten years it seemed to be becoming less effective. Switching to a combination of this glucosamine with MSM helped some but the relief is no longer complete. My reading of all this is that arthritis is the result of a failure in a complex chain of processes and glucosamine is effective against some of the possible failures but not others. This would account for the mixed results in clinical testing as well as my experience since I may have developed an additional point or points of failure. I am suggesting that research is needed to determine what variety of failures may be responsible for the clinical picture we call arthritis so that appropriate treatments can be targeted. By the way, the brand name of the product which was successful for me was “Glucosapure” by JFC Technologies but they don’t seem to have an end user product; look for the Glucosapure branding in the labeling of glucosamine preparations. Further by the way, this is the sulfate form of glucosamine which some other postings have indicated is desirable and they further state that it is “fully reacted” with potassium chloride but I don’t know the significance of this.

  2. I’ve been taking Glucosamine Sulfate for many years. After reading this article, I’m going to stop taking it and see if I notice an increase in pain.

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