Why alcohol affects women more than men

“A woman reaches a higher blood alco­hol level than a man after drinking the same amount of alcohol, even if they’re the same height and weight,” says George Koob, director of the National Institute on Alcohol Abuse and Alcohol­ism at the National Institutes of Health.

That’s mostly because women’s bodies contain less water, notes Koob. And less water means a higher concentration of alcohol in their blood and in their cells after drinking the same amount as men.

But the effect of alcohol is not just a matter of becom­ing impaired more easily. Women who drink regularly are at increased risk of breast cancer.

breast cancer

“Alcohol is related to both premenopausal and postmenopausal breast cancer,” says Walter Willett, chair of the Department of Nutrition at the Harvard T.H. Chan School of Public Health. “And the more you drink, the higher your risk.”

Drinking over more of your life also matters. “Women who started drinking earlier in life and then stopped, their risk goes down,” Willett explains. “The highest risk is in women who started consuming alcohol early and continued.”

And it’s not just heavy drinking

“We now see a 17 percent increased risk with only one drink every other day,” notes Willett. “What’s remarkable is how modest that amount is. With colorectal cancer, you don’t see much increase in risk until you get to over two drinks a day.”

Alcohol’s ability to raise blood estrogen levels appears to explain at least part of the increased risk. “But we’re still not entirely sure whether it’s limited to the increase in estrogen or whether there’s more to it than that,” adds Willett.

“Alcohol is also a stronger risk factor for estrogen-positive cancer than for estrogen-negative breast cancer,” says Regina Ziegler of the Division of Cancer Epidemiology & Genetics at the National Cancer Institute. Estrogen-positive breast cancers are more common in older women.

The American Cancer Society recommends that women limit alcoholic drinks to one a day, if they already consume alcohol.

Does it matter what kind of alcohol?

“It’s the alcohol content that mat­ters,” says Koob. “We don’t see any dif­ference among wine, beer, or distilled spirits in their health effects.”

Drinking can have more conse­quences for women in other ways.

“Females tend to suffer more toxic­ity associated with alcohol across the board,” says Koob. “It makes them more susceptible than males to alcohol-in­duced liver inflammation, cardiovascular disease, accidents, and sexual assault.”

Why are women’s livers more sensi­tive to alcohol? “Truthfully, we don’t know,” says Koob. “But it’s a high priority for re­search at the National Institutes of Health.”


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